|Ecumenical Patriarch of Constantinople|
|Church||Church of Constantinople|
|Installed||4 January 1775|
|Term ended||19 October 1780|
|Died||October 19, 1780|
|Buried||Church of the Asomatoi (Pammegiston Taxiarchon), Arnavutköy|
|Denomination||Eastern Orthodox Church|
Sophronius II (Greek: Σωφρόνιος Β΄), (? – 19 October 1780) served as Ecumenical Patriarch of Constantinople during the period 1775–80 and, as Sophronius V (Σοφρώνιος Ε΄), Greek Orthodox Patriarch of Jerusalem in 1771–75.
In 1775 he was elected Ecumenical Patriarch of Constantinople as Sophronius II. During his reign, a Synod in Constantinople condemned the Kollyvades.
He was an educated and ascetic Patriarch and was especially preoccupied with education and the economics of the Patriarchates he ministered. He died on 19 October 1780 and was buried in the yard of the Church of the Asomatoi (Pammegiston Taxiarchon) in Arnavutköy.