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It includes over 1,500 nuns and is composed of physicians, nurses, lawyers, teachers and social workers. Now it is working in Asia, Europe, Africa and the USA. One of the branch in Kayakkunn near Panamaram, Wayanad District.
Sisters of the Destitute runs many institutions like :
- Homes for the sick and the needy
- Rehabilitation centres for mentally and physically handicapped children
- Health centres for AIDS and cancer patients
- Dispensary for the poor
- Nursing homes